主要研究方向： 1.水产动物疾病与健康养殖 2.细菌耐药基因水平转移机制与病原生物防控 3.肠道健康与微生物调控，益生菌、益生元、抗菌肽、免疫添加剂研发 4.微生物功能因子鉴定与环境治理、养殖尾水处理与养殖工程 5.水产品质量安全与药物残留检测 n 承担科研项目 （1）广东省农业农村厅项目，“水产疫病监测与综合防控共性关键技术研发创新团队”岗位专家，主持，35万，2019/01-2023/12。 （2）2020年省级乡村战略专项资金（渔业发展项目）--广东省水产养殖规范用药项目，主持，50万，2020/01-2022/12 （3）广东省农业农村厅，茂名市2021年省级科技创新战略和乡村振兴战略专项资金（“大专项+任务清单”）--罗非鱼产业链提升，主持，40万，2021/01-2023/12 （4）2019年仲恺农业工程学院国家与省基金培育项目，主持，6万，2019/01-2020/12 （5）国家自然科学基金，青年基金项目编号为31602190，题目：MiR-155靶向踝蛋白抑制柱状黄杆菌诱导EPC细胞凋亡的机制研究，主持，25万，2017/01-2019/12。 （6）博士后自然科学基金，面上基金资助编号2016M602327，题目：miRNA-155调节柱状黄杆菌诱导EPC细胞凋亡的机制研究，主持，5万，2017/01-2018/12。 n 代表论著 1. Liu G, Vijayaraman SB, Dong Y, Li X, Andongmaa BT,Zhao L, Tu J, He J, Lin L*. Bacillus velezensis LG37: transcriptome profiling and functional verification of GlnK and MnrA in ammonia assimilation. BMC Genomics. 2020 Mar 6;21(1):215. SCI:3.501.（JCR一区刊物） 2. FeiShi, YingjuanZi, ZhijieLu, FenglinLi, MinxuanYang, FanbinZhan, YananLi, JunLi,LijuanZhao, LiLin, ZhendongQin ,Bacillus subtilis H2 modulates immune response, fat metabolism and bacterial flora in the gut of grass carp (Ctenopharyngodon idellus).Fish and Shellfish Immunology，2020.106:8-20. 3. Zhendong Qin, V. Sarath Babu, Hanzuo Lin, Yunjia Dai,Lijuan Zhao, Jungang Xie, Weiqiang Lin, Zaohe Wu, Jun Li*, Li Lin*. Antibacterial activity of erythrocyte from grass carp (Ctenopharyngodon idella) is associated with phagocytosis and reactive oxygen species generation. Fish Shellfish Immunol. 2019, accepted. SCI:3.02.（JCR一区刊物）. 4. Muhammad Asim, V. Sarath Babu, Zhendong Qin,Lijuan Zhao, Jianguo Su, Jun Li, Jiagang Tu, Hongyan Kou*, Li Lin*. Inhibition of Cyclophilin A on the Replication of Red Spotted Grouper Nervous Necrosis Virus associates with multiple pro-inflammatory factors. Fish Shellfish Immunol. 2019, accepted. SCI:3.02.（JCR一区刊物）. 5. Zhendong Qin, V. Sarath Babu, Hanzuo Lin, Yunjia Dai, Hongyan Kou, Liehuan Chen, Jun Li,Lijuan Zhao*, Li Lin*.The immune function of prophenoloxidase from red swamp crayfish (Procambarus clarkii) in response to bacterial infection.Fish Shellfish Immunol. 2019, accepted. SCI:3.02.（JCR一区刊物）. 6. Farman Ullah Dawar, Sarath Babu V, Hongyan Kou, Zhendong Qin, Quanyuan Wan,Lijuan Zhao, Muhammad Nasir Khan Khattack, Jun Li, Jie Mei*, Li Lin*.The rag 2 gene of yellow catfish (Tachysurus fulvidraco) and its immune response againstEdwardsiella ictaluriinfection. Dev Comp Immunol, 2019,16;98:65-75.2019. SCI IF:2.815.（JCR一区刊物） 7. Xiaodan Liu, Zhendong Qin, Sarath Babu V,Lijuan Zhao, Jun Li, Xiaojun Zhang, Li Lin*. Transcriptomic profiles of striped snakehead cells (SSN-1) infected withsnakehead vesiculovirus (SHVV) identifying IFI35 as a positive factor forSHVV Replication. Fish Shellfish Immunol. 2019 Mar;86:46-52,SCI:3.02.（JCR一区刊物）. 8. Meng Zhou, Quanyuan Wan, Sarath Babu V, Qiongju Qiu, Hongyan Kou, Chong Lin,Lijuan Zhao, Ling Yang, Jun Li, Yunmao Huang*,Li Lin*.Bacterial features in tilapia (Oreochromis niloticus) and environments in a goose-tilapia polyculture model. Aquaculture, 2018, 497: 313-319, SCI:2.57.（JCR Q1）. 9. Zhendong Qin+, V Sarath Babu+, Ningqiu Li, Tairan Fu, Jinquan Li, Lizhu Yi,Lijuan Zhao, Jun Li, Yang Zhou*,Li Lin*.Protective effects of chicken egg yolk immunoglobulins (IgY) against experimentalAeromonas hydrophila infection in Blunt snout bream (Megalobrama amblycephala) .Fish Shellfish Immunol. 2018 Jul;78:26-34. SCI:3.02.（JCR一区刊物）. 10. Zhendong Qin, V. Sarath Babu, Quanyuan Wan, Meng Zhou, Risheng Liang, Asim Muhammad,Lijuan Zhao, Jun Li, Jiangfeng Lan* , Li Lin*. Transcriptome analysis of Pacific white shrimp (Litopenaeus vannamei) challenged byVibrio parahaemolyticusreveals unique immune-related genes .Fish Shellfish Immunol. 2018 Jun;77:164-174. SCI:3.02.（JCR一区刊物）. 11. Xiaolei Wei, V. Sarath Babu, Li Lin, Yazhen Hu, Yulei Zhang, Xiaoling Liu, Jianguo Su, Jun Li,Lijuan Zhao*, Gailing Yuan*· Hepcidin protects grass carp (Ctenopharyngodon idellus) against Flavobacterium columnare infection via regulatin iron distribution and immune gene expression. Fish & Shellfish Immunology, 75: 274-283. April 2018.（JCR一区刊物） 12. Chi Zhang, Shuangshuang Feng, Wenting Zhang, Nan Chen, Abeer Hegazy,Wenjie Chen, Xueqin Liu,Lijuan Zhao, Jun Li, Li Lin* and Jiagang Tu*. MicroRNA miR-214 Inhibits Snakehead Vesiculovirus Replication by Promoting IFN-α Expression via Targeting Host Adenosine 5’-Monophosphate-Activated Protein Kinase. Frontiers in Immunology, 2017 Dec 11;8:1775. SCI: 6.4.（JCR一区刊物）. 13. Farman Ullah Dawar, Xianqin Hu, Lijuan Zhao, Xingxing Dong, Yang Xiong, Meng Zhou, Rishen Liang, V Sarath Babu, Jun Li, Jie Mei*, Li Lin* .Transcriptomic analysis reveals differentially expressed genes and a unique apoptosis pathway in channel catfish ovary cells after infection with the channel catfish virus. Fish Shellfish Immunol. 2017 Sep 29;71:58-68. SCI:3.02.（JCR一区刊物）. 14. Zhang Y,Zhao L*, Chen W, Huang Y, Yang L, Sarathbabu V, Wu Z, Li J, Nie P*,Lin L*.Complete genome sequence analysis of the fish pathogen Flavobacterium columnare provides insights into antibiotic resistance and pathogenicity related genes.Microb Pathog. 2017 Sep 1;111:203-211 SCI : 2.0.（JCR三区刊物） 15. Lin Q, Fu X, Li N, Wan Q, Chen W, Huang Y, Huang Z, Li J,Zhao L*,Lin L*. Co-infections of infectious spleen and kidney necrosis virus and Siniperca chuatsi rhabdovirus in Chinese perch (Siniperca chuatsi).Microb Pathog. 2017 Sep 7;111:422-430. SCI : 2.0.（JCR三区刊物） 16. Lindan Sun+, Jiagang Tu+, Lizhu Yi, Wenjie Chen,Lijuan Zhao, Yunmao Huang, Rishen Liang, Jun Li, Meng Zhou*, Li Lin*. Pathogenicity of snakehead vesiculovirus in rice field eels (Monopterus albus). Microb Pathog. 2017 Sep;110:578-585. SCI : 2.0.（JCR三区刊物） 17. Chi Zhang, Lizhu Yi, Shuangshuang Feng, Xueqin Liu, Jianguo Su,Li Lin, Jiagang Tu*.MicroRNA miR-214 inhibits snakehead vesiculovirus (SHVV) replication by targeting the coding regions of viral N and P.Journal of General Virology,2017 Jul;98(7):1611-1619. SCI IF :3.2.（JCR三区刊物） 18. Jiali Jin+, Yao Wang+, Zhixin Wu, Abeer Hergazy, Jiangfeng Lan,Lijuan Zhao，Xiaoling Liu, Nan Chen*, Li Lin*.Transcriptomic analysis of liver from grass carp (Ctenopharyngodon idellus) exposed to high environmental ammonia reveals the activation of antioxidant and apoptosis pathways.Fish Shellfish Immunol. 2017 Apr;63:444-451 SCI:3.02.（JCR一区刊物） 19. Wenjie Chen, Lizhu Yi, Shuangshuang Feng,Lijuan Zhao, Jun Li, Meng Zhou, Rishen Liang, Na Gu, Zaohe Wu, Jiagang Tu*, Li Lin*. Characterization of microRNAs in orange-spotted grouper (Epinephelus coioides) fin cells upon red-spotted grouper nervous necrosis virus infection.Fish Shellfish Immunol. 2017,63:228-236. SCI:3.02.（JCR一区刊物） 20. Ze Zhang, Angen Yu, Jiangfeng Lan, Hua Zhang , Minqiang Hu, Jiewei Cheng,Lijuan Zhao, Li Lin*, Shun Wei*. GapA, a potential vaccine candidate antigen against Streptococcus agalactiae in Nile tilapia (Oreochromis niloticus). Fish Shellfish Immunol. 2017, 63:255-260.SCI:3.02.（JCR一区刊物） 21. Yun-Jia Dai,Kai-Min Hui,Ying-Hao Zhang,Yan Liu,Yu-Qing Wang, Li-Juan Zhao,Li Lin,Lian-Qin Chai, Shun Wei, Jiangfeng Lan.Three STATs are involved in the regulation of the expression of antimicrobial peptides in the triangle sail mussel,Hyriopsis cumingii.Fish Shellfish Immunol. 2017 Apr;63:181-188.SCI:3.02.（JCR一区刊物） 22. Xiaozhe Fu, Xianqin Hu, Ningqiu Li*, Feifei Zheng, Xingxing Dong, Jing Duan, Qiang Lin, Jiagang Tu, Lijuan Zhao, Zhibin Huang, Jianguo Su,Li Lin*. Glutamine and glutaminolysis are required for efficient replication of infectious spleen and kidney necrosis virus in Chinese perch brain cells.Oncotarget, 2017, Vol. 8, (No. 2), pp: 2400-2412. SCI :5.08 (JCR一区刊物). 23. Farman Ullah Dawar, Junjie Wu,Lijuan Zhao, Muhammad Nasir Khan Khattak, Jie Mei*, Li Lin*. Updates in understanding the role of cyclophilin A in leukocyte chemotaxis.Journal of Leukocytes Biology. 2017 Apr;101(4):823-826 ; SCI IF :4.16.（JCR一区刊物） 24. Yunjia Dai, Yuqing Wang, Yinghao Zhang,Yan Liu, Jinquan Li, Shun Wei, Lijuan Zhao,Yongcan Zhou,Li Lin*, Jiangfeng Lan*.The role of ficolin-like protein (PcFLP1) in the antibacterial immunity of red swamp crayfish (Procambarus clarkii).Molecular Immunology. 2016 Nov 23;81:26-34. SCI:3.23(JCR三区刊物) 25. Muhammad Asim, Sanjie Jiang, Lizhu Yi, Wenjie Chen, Lindan Sun, Lijuan Zhao, Muhammad Nasir Khan Khattak, Jiagang Tu*,Li Lin*. Glutamine is required for red-spotted grouper nervous necrosis virus replication via replenishing the tricarboxylic acid cycle. Virus Research. 2016, 227:245-248. SCI :2.7（JCR三区刊物） 26. Jiangfeng lan, Lijuan Zhao, Shun Wei, Yuan Wang,Li Lin, Xincang Li. PcToll2 positively regulates the expression of antimicrobial peptides by promoting PcATF4 translocation into the nucleus. Fish Shellfish Immunol. 2016 Sep 10;58:59-66. SCI:3.02.（JCR一区刊物） 27. Lindan Sun, Lizhu Yi, Chi Zhang, Xiaodan Liu, Shuangshuang Feng, Wenjie Chen, Jiangfeng Lan,Lijuan Zhao, Jiagang Tu*, Li Lin*. Glutamine was required for snakehead fish vesiculovirus (SHVV) propagation via replenishing the tricarboxylic acid cycle.Journal of General Virology, 2016 Nov;97(11):2849-2855. SCI IF :3.2（JCR三区刊物） 28. Jiang-Feng Lan, Shun Wei, Yu-Qing Wang, Yun-Jia Dai, Jia-Gang Tu,Li-Juan Zhao, Xin-Cang Li, Qi-Wei Qin, Nan Chen*, Li Lin*. PcToll3 positively regulates the expression of antimicrobial peptides by promoting PcDorsal translocation into nucleus in red swamp crayfish,Procambarus clarkii. Fish and Shellfish Immunology, 2016, 57:17-24. SCI:3.02.（JCR一区刊物） 29. Lijuan Zhao+, Jiagang Tu+, Yulei Zhang, Jinfu Wang, Ling Yang, Weimin Wang, Zaohe Wu, Qinglei Meng*,Li Lin*.Transcriptomic analysis of the head kidney of Topmouth culter (Culter alburnus) infected with Flavobacterium columnare with an emphasis on phagosome pathway. Fish and Shellfish Immunology, 2016 Oct;57:413-8. SCI:3.02.（JCR一区刊物） 30. Yao Wang, Nan Chen, Abeer M. Hegazy, Xiaodan Liu, Zhixin Wu , Xueqin Liu,Lijuan Zhao, Qiwei Qin, Jiangfeng Lan*, Li Lin*. Autophagy induced by Snakehead fish vesiculovirus inhibited its replication in SSN-1 cell line.Fish and Shellfish Immunology, 2016, 55:415-422. SCI:3.02.（JCR一区刊物） 31. Zhao LL, Wang YQ, Dai YJ, Zhao LJ, Qin Q,Lin L, Ren Q, Lan JF. A novel C-type lectin with four CRDs is involved in the regulation of antimicrobial peptide gene expression inHyriopsis cumingii. Fish and Shellfish Immunology, 2016, 55:339-347. SCI:3.02.（JCR一区刊物） 32. Yunjia Dai, Yuqing Wang, Lingling Zhao, Zhendong Qin, Junfa Yuan, Qiwei Qin,Li Lin*, Jiangfeng Lan*. A novel L-type lectin was required for the multiplication of WSSV in red swamp crayfish (Procambarus clakii). Fish and Shellfish Immunology, 2016, 55:48-55. SCI : 3.02.（JCR一区刊物） 33. Jiagang Tu+, Wenjie Chen+, Xiaozhe Fu, Qiang Lin, Ouqin Chang,Lijuan Zhao,Jiangfeng Lan*, Ningqiu Li *, Li Lin *.Susceptibility of Chinese perch brain (CPB) cell and Mandarin fish to Red-spotted grouper nervous necrosis virus (RGNNV) infection.Int J Mol Sci. 2016, May 19;17(5). pii: E740. doi: 10.3390/ijms17050740. SCI IF : 3.2（JCR四区刊物） 34. Zhao L, Lu H, Meng Q, Wang J, Wang W, Yang L*,Lin L*. 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Xianqin Hu, Xiaozhe Fu, Ningqiu Li*, Xingxing Dong,Lijuan Zhao,Jiangfeng Lan,Wei Ji,Weidong Zhou, Taoshan Ai, Shuqin Wu, Li Lin*. Transcriptomic analysis of Mandarin fish brain cells infected with infectious spleen and kidney necrosis virus with an emphasis on retinoic acid-inducible gene 1-like receptors and apoptosis pathways. Fish and Shellfish Immunology, 2015, 45 : 619-629. SCI IF: 2.674..（JCR一区刊物） 38. Li Juan Zhao，Jin Fang Lu，P. Nie, Ai Hua Li, Bang Xi Xiong, Hai Xia Xie. Roles of plasmid-encoded proteins, EseH, EseI and EscD in invasion, replication and virulence of Edwardsiella ictaluri.Veterinary Microbiology, 2013, 166, 233–241.（JCR一区刊物） 39. Shan Nan Chen, Bei Huang, Xiao Wen Zhang, Ye Li,Li Juan Zhao, Nan Li, Qian Gao, P. Nie. IFN-c and its receptors in a reptile reveal the evolutionary conservation of type II IFNs in vertebrates. 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